Dr. Keith J. Fritzsching

Position(s)
PhD Candidate, Chemistry, Brandeis University. (2014)
Graduate Student, Chemistry, Iowa State University. (2012)
Degree(s)
B.S. (Department of Chemistry and Biochemistry, Arizona State University)
Email
kfritzsc@brandeis.edu
Biography
I am interested in determining the structure and dynamics of partially disordered and complex macromolecular systems, in particular protein aggregates and semicrystalline polymers. My primary experimental tool has been solid-state NMR. Much of my work relies on spin dynamics based computation and database-driven analysis to develop SSNMR methods and understand results.

Publications

  1. Robert J. Comito , Keith J. Fritzsching , Benjamin J. Sundell , Klaus Schmidt-Rohr and Mircea Dinca; # "Single-Site Heterogeneous Catalysts for Olefin Polymerization Enabled by Cation Exchange in a Metal-Organic Framework" J. Am. Chem. Soc. : (2016).
  2. Samantha A. Burgess , Abebu Kassie , Sarah A. Baranowski , Keith J. Fritzsching , Klaus Schmidt-Rohr , Craig M. Brown and Casey R. Wade # "Improved Catalytic Activity and Stability of a Palladium Pincer 2 Complex by Incorporation into a Metal−Organic Framework" J. Am. Chem. Soc. 138: 1780-1783 (2016).
  3. Keith J. Fritzsching # , Mei Hong and Klaus Schmidt-Rohr # "Conformationally selective multidimensional chemical shift ranges in proteins from a PACSY database purged using intrinsic quality criteria" J. Biomol. NMR 64: 115-130 (2016).
  4. Shu Yu Liao * , Keith J. Fritzsching * and Mei Hong # "Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR" Protein Science 22: 1623-1638 (2013).
  5. Keith J. Fritzsching , Jihyun Kim and Gregory P. Holland # "Probing lipid–cholesterol interactions in DOPC/eSM/Chol and DOPC/DPPC/Chol model lipid rafts with DSC and 13C solid-state NMR" BBA - Biomembranes 1828: 1889-1898 (2013).
  6. Yu Yang , Keith J. Fritzsching and Mei Hong # "Resonance assignment of the NMR spectra of disordered proteins using a multi-objective non-dominated sorting genetic algorithm" J. Biomol. NMR 57: 281-296 (2013).
  7. Keith J. Fritzsching , Y. Yang , Klaus Schmidt-Rohr and Mei Hong # "Practical Use of Chemical Shift Databases for Protein Solid-State NMR: 2D Chemical Shift Maps and Amino-Acid Assignment with Secondary-Structure Information" J. Biomol. NMR 56: 155-167 (2013).
  8. Mei Hong # , Keith J. Fritzsching * and Jonathan K. Williams * "Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shifts." J Am Chem Soc 134: 14753-14755 (2012).
  9. Klaus Schmidt-Rohr , Keith J. Fritzsching , T. Wang , S. Y. Liao and Mei Hong # "Spectral Editing of Two-Dimensional Magic-Angle-Spinning Solid-State NMR Spectra for Protein Resonance Assignment and Structure Determination" J. Biomol. NMR 54: 343 (2012).